R&D

HysensBio Odontoblast Reactivation

HysensBio opens a new era of dental treatment with our first-in-class dentin regeneration technology of KH-001 peptide.

·  Dentin hypersensitivity is one of the most common incurable diseases, such as dental caries and periodontal diseases

·  Dentin regeneration is a fundamental solution for alleviating pain from dentin hypersensitivity, dental caries, and other dental diseases

·  We aim to establish our KH-001 Peptide Dentin Regeneration Technology as the most powerful treatment for 2.3B caries patients, in $40B market of dentin hypersensitivity & dental caries, and in $6B market of toothpaste & mouthwash

What Causes Tooth Pain & Why Pain Cannot be Recovered

KH-001: Dentin Hypersensitivity Treatment

Development of ‘First-in-Class’ dentin hypersensitivity treatment by regenerating physiologic dentin and restoring damaged dentin thickness

World’s First Native Dentin Regeneration

World’s First Native Dentin Regeneration

KH-001 Acceptance of Dental Staff

+85% of Dental Staffs are willing to use KH001

KH001 Acceptance of Dental Staff

KH-002: Dental Caries Treatment

Activate odontoblasts in cavity-affected area · Occlude dentinal tubules · Block bacteria progression
· Regenerate dentin & Eliminate inflammation

KH-001: Dental Caries Treatment

HBO-001: Rare Disease - Amelogenensis imperfecta treatment

Amelogenensis imperfecta: Relieving extreme pain - primary treatment

Improved pain caused by amelogenesis imperfecta, a rare disease with dentin
regeneration technology through odontoblast activation

Amelogenensis imperfecta

· Symptom : Extreme pain resulting from tooth wear/breakage/loss/cavities due to incomplete formation of enamel
and subsequent sensitive irritation responses

· Prevalence : 1 in 700 individuals (Sweden) ~ 1 in 14,000 (US)

· Rare disease status : Designated in the US

· Currently applying for FDA orphan drug designation

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Nonclinical Data