HysensBio PDL Fibroblast Reactivation
KH-201: Periodontitis Treatment
· Etiology: Inflammation of gingiva (gum), periodontal ligament and bone tissue
· Symptom: Swelling and bleeding of the gum due to inflammation, development of periodontal pocket, tooth loss due to damage to the periodontal ligament and alveolar bone.
· Surgical Methods: Scaling, Root Planing, Gingival Curettage, Periodontium Regeneration (Limitations in regenerating the already damaged periodontium.)
· Nonsurgical Methods: Antibiotics, Anti-inflammatory drugs (No treatment that prevents destruction of gingiva and alveolar bone.)
for Periodontal Diseases
· Representative dental disease that more than 80% of the people suffer from, 970M periodontitis patients WW (as of 2017), expected to increase to more than 1.5B by 2050 (WHO, 2019)
· The ultimate aim of periodontal treatment is to regenerate periodontium damaged by periodontal diseases, more specifically to restore the function of periodontium via regeneration of the periodontal ligament between the cementum damaged by inflammation and the alveolar bone, and enhanced attachment of the periodontal ligaments to the surrounding components.
· Induction of periodontal ligament re-adhesion to the cementum and the alveolar bone, along with inhibition of its calcification are the core techniques to be solved for regenerating tooth-periodontium complex structure, which includes tooth, periodontal membrane, and alveolar bone.
MOA of KH-201
· KH-201 regenerates cementum on the surface of root dentin
· KH-201 regenerates periodontal ligament(PDL)
· Newly formed periodontal ligament is vertically aligned and attached to the newly formed cementum layer
Journal of Clinical Periodontology (IF: 8.7, JCR, Dentistry: 1/92)
Published as the cover paper of the June 2022 issue
HB-901: Veterinary Dental Medicine
Oral healthcare of companion animals – Developing as growth momentum
HB-901 can be used for prevention and treatment purposes in early stages of periodontal disease in animals
Confirmed periodontal tissue regenerative function of HB-901
in nonclinical tooth replantation model
